Staging Diagnosis Of Chronic Renal Failure In Children

Time :Jan 27, 2019    Views :148

What are the staging diagnosis of Chronic Renal Failure in children? More and more patients consult ONLINE DOCTOR about it, following this article to get answer. 
(1) Compensation period of Renal Insufficiency: serum Creatinine was 110-177 micromol/L (1.2-2 mg/dl), and the remaining GFR was 50-80%. There were no clinical symptoms.

(2) Decompensated stage of renal insufficiency (azotemia): serum creatinine is 178-445 micromol/L (2-5 mg/dl), and the remaining GFR is 25-50%. There may be mild anemia, acidosis, nocturia and fatigue.

(3) Renal failure stage (uremic stage): Cr446-707 micromol/L (5-8 mg/dl), the remaining 10-25% of GFR, with obvious digestive tract symptoms and signs of anemia, metabolic acidosis and abnormal metabolism of calcium and phosphorus.

(4) End Stage Renal Disease: Cr is greater than or equal to 708 micromol/L (8mg/dl), the remaining GFR is less than 10%. There are various uremic symptoms, including dysfunction of digestive, nervous and cardiovascular systems, disorder of water and salt metabolism, obvious acid-base imbalance, severe anemia and so on.

It is clear that there are many causes of CRF caused by the diagnosis of primary diseases, such as edema caused by glomerular diseases and abnormal urine. However, some patients had insidious symptoms and no history of renal disease. Some symptoms such as poor acceptance, inactivity, nocturia or enuresis are not specific. There are also patients with anemia, refractory rickets, growth retardation, polydipsia and polyuria who need to undergo careful physical examination, urine examination (including specific gravity), blood biochemical and renal function tests and timely detection of CRF, and try to find the cause.

For example, renal dysplasia caused by congenital malformations of urinary system, polycystic kidney, and renal failure caused by hereditary diseases such as Alport syndrome, the onset age is earlier. Symptoms occur at the age of 1 to 2. Often no edema, short stature, renal osteopathy more common. CRF caused by glomerular diseases is more common in older children, often more than 5 years old. It can be accompanied by anemia, hypertension, edema, moderate proteinuria, hematuria, low specific gravity urine, or secondary urinary tract infection. The acute onset of renal failure should be differentiated from acute renal failure.

The clinical manifestations of both groups are similar, and the etiology and inducement are partly the same. However, the prognosis of most patients with acute renal failure is good, and a small number of patients can gradually develop to CRF after convalescence. Chronic renal insufficiency caused by congenital or hereditary kidney diseases is more common in children than in adults, and congenital dysplasia of urinary system is more common in children, while congenital or hereditary kidney diseases in adults mainly occur in congenital polycystic kidney.

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