Diabetic Nephropathy (DN) is one of the complications of diabetic systemic microangiopathy. Therefore, DN often occurs in combination with other organ or system microangiopathy such as diabetic retinopathy and peripheral neuropathy.
Diabetic nephropathy in patients with type 1 diabetes mellitus usually occurs in about 10-15 years of onset, while diabetic nephropathy in patients with type 2 diabetes mellitus occurs in a short period of time, which is associated with older age and more other underlying diseases.
Diabetes mellitus occurs mainly in the elderly, so how to treat the disease is very critical, then the treatment of the disease are:
1. Hypertensive drug therapy: In the treatment of diabetic nephropathy, hypertensive drug therapy is also indispensable, that for diabetic patients, the current choice of drugs are angiotensin-converting enzyme inhibitors (ACEI), calcium antagonists (CCB) and angiotensin II receptor antagonists, especially for the existing hypertension of sugar ACEI is not only safe and effective in patients with urinary nephropathy, but also can improve renal function and reduce UAE in diabetics with normal blood pressure but also with persistent microalbuminuria.
2. Adoption of glycemic manipulation: Clinical and experimental studies have shown that metabolic disorders and chronic hyperglycemia in patients are a major cause of this disease, but also very good proof that through insulin subcutaneous continuous infusion therapy to control blood glucose, can be very effective in controlling the progress of kidney disease.
3. Require patients to have a high-quality low-protein diet: and preferably in the early stage of diabetic nephropathy to start with a high-quality low-protein diet, if found to have edema and hypertension should be limited sodium and low-salt diet.
4. Effective control of hypertension: hypertension can not only accelerate the progression of diabetic glomerular damage, but also aggravate diabetic retinopathy. And it was found that controlling hypertension effectively reduced urinary protein excretion and slowed down the rate of kidney function decline, thus prolonging life expectancy, so this is a better treatment for diabetic nephropathy.
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