What are the differences between hypertension and nephropathy? How does hypertension develop into kidney disease? Why does hypertension develop into nephrosis and the body does not have obvious signals?
Hypertension is closely related to kidney. Hypertension can cause kidney damage, and many kidney diseases are prone to hypertension. Hypertension and kidney disease interact with each other, causing each other to cause a vicious circle.
Hypertension is a cardiovascular disease, and the kidney is also composed of small blood vessels of the organs, long-term hypertension also damages the small arteries of the kidney, hypertension causes spasm of small renal arteries, leading to renal vascular ischemia and hypoxia, and then damage the glomerular endothelial cells. Once damaged, endothelial cells will attract inflammatory cells in the blood circulation infiltration, and release pathogenic inflammatory mediators, at this time the local pathological changes of glomerulus: changes in the glomerular basement membrane, filter hole enlargement, damage to the charge barrier, increased renal permeability, at this time proteinuria will appear.
Most hypertensive patients have different degrees of kidney changes, but the occurrence of hypertensive nephropathy is a slow process. Essential hypertension develops steadily in general. Mild to moderate renal arteriosclerosis can occur in 5 to 10 years, and then damage the renal unit. It often occurs in patients with long-term hypertension without good control. In mild to moderate essential hypertension, the early course of the disease is quite a long period of time, due to the role of the kidney itself, there is no change in the structure and function of the kidney, only when the kidney of this self-regulation function decline, high sodium load in the state of hypertension and acute volume expansion and other pathological conditions, experienced a certain amount of time. After the time, renal tubular injury and functional damage gradually appear.
The relationship between hypertension and kidney is very complicated and close, and they are causal to each other in different situations. Long-term hypertension will inevitably affect the kidneys, and kidney structure and function changes, but also lead to hypertension. In both cases, elevated blood pressure and kidney damage can aggravate each other, forming a vicious circulatory chain. It is precisely because hypertension is closely related to kidney disease, it is recommended that patients with hypertension should regularly go to the hospital to check urine and kidney function. In daily life, you should also pay attention to whether you have edema, increased night urine, and foam in urine. Once these symptoms indicate that there may be renal damage, they should be treated in hospital.
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